Research in phytochemical composition and hypoglycemic activity screening of the dry extracts from bearberry leaves

Diabetes mellitus is a global medical and social issue. In the developed countries of world, from 5 to 12% population are diagnosed with diabetes and, according WHO prognosis, level this disease may increase 30-35%. Type 2 that progresses over time, but rational systematic use hypoglycemic synthetic drugs phytopreparations can significantly delay onset insulin therapy. A promising source BAS effect raw material plants Heather family, namely, bearberry leaves. However, on Ukrainian market there no domestic galenic novo-galenic preparations based biologically active substances material, which indicates prospects for development new drugs, including those action. The aim. aim study was phytochemical composition carry out screening activity dry extracts leaves modified various amino acids identify Materials methods. objects were 11 leaves, 10 acids. phenolic compounds carried by TLC, HPLC, spectrophotometry. To assess extracts, two experiments - primary oral glucose tolerance test. Results. Using TLC in obtained arbutin, gallic acid, flavonoids identified, among hyperoside dominant, 4 hydroxycinnamic acids, chlorogenic caffeic their content established. obtained, main groups quantified using spectrophotometric method. Dry cysteine, arginine glutamic showed strongest activity. Conclusions. chemical different determined. most turned be acid; therefore, they agents drugs.